American Board of Psychiatry and Neurology (ABPN) Practice Exam

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What is the most common side effect of SSRIs early in treatment that may lead to discontinuation by patients?

Sleeplessness
Sexual dysfunction
Gastrointestinal distress
Headache

The correct answer is: Gastrointestinal distress

The most common side effect of SSRIs early in treatment that may lead to discontinuation by patients is gastrointestinal distress. This side effect can manifest as nausea, diarrhea, or other digestive issues and often occurs shortly after starting the medication. Patients frequently find gastrointestinal symptoms to be bothersome, particularly if they are significantly disruptive to their normal daily activities. As a result, this discomfort can influence their decision to stop taking the medication even before they have had the chance to experience its full therapeutic effects. Many patients may not be prepared for these side effects, causing anxiety and frustration that further contribute to the desire to discontinue the SSRI. Although sexual dysfunction, sleeplessness, and headaches are also associated with SSRIs, they tend to occur less frequently during the initial treatment phase compared to gastrointestinal distress. Understanding the common side effects associated with SSRIs can help clinicians prepare patients for what to expect, providing reassurance and strategies to manage these adverse effects, which may improve treatment adherence.